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Relationship between TDP-43-controlled immune mediators and neuronal dysfunctions/viral infection. Regulation of TDP-43 levels contributes to increase or reduce the expression of different immune mediators, such as IL-1β, NF-κB, IL-6, ICAM-1, and TNF-α. Up- and downregulated effects are indicated with upward and downward arrows, respectively. Neurodegenerative and viral implications are also reported in the table.
