Table 4.
Dissolution of solid target for GE PETtrace cyclotron and purification of [68Ga]GaCl3.
| Target Dissolution |
Separation of Target Material and Purification | Formulation | Time (min) | EOP (GBq) | [68Ga]GaCl3 Molarity (Volume) | EOS (GBq) | AMA (GBq/µmol) | Ref. |
|---|---|---|---|---|---|---|---|---|
| S: 7 M HCl V: 0.5 mL |
R: TK400 resin C: 7M HCl (5 mL) W: 7 M HCl (28 mL), 0.05 M HCl (0.7 mL) E: 0.05 M HCl (3.5 mL) |
NA | 32 a | 3.31 | 0.05 M HCl (3.5 mL) | 1.56 b | 7.1 | [38] |
| S: 10 M HCl V: 10 mL T: <10 min |
R: 5 g of 50W-X4 C: 10 M HCl (25 mL) W: 10 M HCl (30 mL) E: 4 M HCl (12 mL) |
R: 100 mg UTEVA® C: 4 M HCl (10 mL) W: 4 M HCl (10 mL) E: 0.05 M HCl (2 mL) |
10 | NR | 0.05 M HCl (2.0 mL) | NR | 6.7 ± 0.8 | [22] |
| S: 9.5 M HCl V: 2 mL T: 2 min |
R: UTEVA L: Pre-dilution4 M HCl (11.5 mL) W: 10 mL of 4 M, HCl and 10 mL of 2.5 M HCl E: 2 mL water and re-distributed into 10 mL of 4 M HCl |
R: UTEVA W: 20 mL of 2.5 M HCl E: 1 mL water |
23 | 18 ± 2 | Water (1 mL) | 86 ± 22 c | [34] | |
| S: 30% HCl (~90 °C) V: 2 mL |
R: 250 mg ZR resin. W:15 mL of 30% HCl E: 8 mL of 1 M HCl and passed through a LN Resin |
R: TK200 resin. W: Nitrogen purging E: 2.5 mL of 0.1 M HCl |
35 | 194 d | 0.1 M HCl (2.5 mL) | 72.2 | 25 e | [32] |
S: Solution; V: Volume; T: Time; R: Resin; C: Conditioning; L: Load W: Wash; E: Elution; NR: Not reported. a From dissolution until end of purification; b 68Zn target (23 mg) was irradiated at 14.5 MeV and 30 mA for 15 min to give 6.30 GBq; c DOTA; d Production run number 4; e DOTA.