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. 2022 Dec 26;15(1):70. doi: 10.3390/pharmaceutics15010070

Table 7.

Methods for separation of target material and purification and formulation of [68Ga]GaCl3.

Process Method Result Ref.
Separation of target material and purification, and formulation Platform: FastLab2 Developer, GE Healthcare, Wisconsin, USA
Purification: Zr Resin washed with 0.1 M HNO3 (9 mL), elute with 2 M HCl (5 mL)
Formulation: TK200, elute with 0.1 N HCl (5 mL)
EOS = 2.3 ± 0.2 GBq [35]
Platform: Trasis All-in-One, Belgium
Purification: 100 mg, hydroxamate resin (50–100 μm); washed with of 0.005 M HNO3 (50 mL); elute with of 5.5 M HCl (7 mL).
Formulation: 400 mg, AG-1X-8 anion exchange resin; elution with 2 mL of water.
NR [36]
Platform: FastLab2 Developer, GE Healthcare, Milwaukee, WI, USA
Purification: Zr Resin; condition with 0.1 M HNO3 (7 mL); washed with 0.1 M HNO3 (15 mL), elution with 1.75 M HCl (5–6 mL).
Formulation: TK200 resin; condition with water (7 mL) followed by 1.75 M HCl (4 mL) before use; washed with 2.0 M NaCl (3.5 mL) in 0.13 M HCl; elute with 1–2 mL H2O followed by dilute HCl to formulate
EOS= 2.0  ±  0.3 GBq
50 mCi
[37]