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Synthetic pathway for the synthesis of an intermediate 1,4-dihydropyrimidinethione by multi-component reaction involving thiourea, 3-nitrobenzaldehyde, and ethyl acetoacetate boiled under ethanol and 37% HCl conditions. The intermediate was further used to synthesize DHPM derivatives to obtain 2-aroylmethylsulfanyl derivative, 2-aryl-2-hydrozyvinyl derivative, and 1,3-dioxoisoindolin-2-ylpropylsulfanylderivatives (the reagents and the experimental conditions are mentioned).
