Table 3.
Coagulation markers pre- and post-vaccination in T2DM patients. Data are expressed as median and IQR. p Values were calculated by means of the Friedman test (n = 37). Abbreviations: APTT, activated partial thromboplastin time; PT, prothrombin time. a see references [11,14]; b reference values do not exist.
| Baseline Median [IQR] |
Visit 1 Median [IQR] |
Visit 2 Median [IQR] |
p Value (Friedman) |
Reference Values a | |
|---|---|---|---|---|---|
| CRP [mg/L] Standard coagulation markers APTT [s] PT [%] D-Dimer [µg/mL] Fibrinogen [mg/dL] Haemoglobin [g/dL] Platelets [106/µL] |
2 [1–4] 31 [29–34] 120 [112–120] 0.32 [0.26–0.41] 288 [264–338] 15 [14–16] 238 [207–284] |
2 [1–3] 32 [29–34] 120 [113–120] 0.32 [0.27–0.46] 295 [270–340] 15 [14–16] 257 [215–309] |
2 [1–3] 31 [29–34] 120 [116–120] 0.40 [0.29–0.56] 304 [270–337] 15 [14–16] 243 [208–283] |
0.824 0.530 0.100 0.001 0.342 0.766 0.061 |
<3 30–40 70–130 0–0.5 180–350 13 [12–15] 250 [125–318] |
| Thrombelastometry Coagulation time [s] Clot formation time [s] Maximum clot firmness [mm] Alpha angle [°] |
240 [220–285] 181 [134–252] 56 [51–61] 58 [50–64] |
240 [211–263] 148 [128–181] 61 [58–65] 61 [58–64] |
247 [223–293] 154 [135–193] 60 [56–64] 60 [56–65] |
0.241 0.034 0.001 0.049 |
256 ± 25 139 ± 40 58 ± 5 64 ± 7 |
| Platelet aggregation Amplitude [Ohm] Slope [Ohm/min] Lag time [s] |
11 [9–14] 6 [4–8] 91 [76–119] |
12 [9–14] 7 [5–8] 93 [83–130] |
12 [9–13] 7 [5–9] 90 [71–115] |
0.593 0.433 0.206 |
13.6 ± 1.4 8.4 ± 2.0 58.6 ± 9.7 |
| Thrombin generation Lag time [min] Thrombin potential [nM·min] Peak [nM] Time to Peak [min] VelIndex [nM/min] StartTail [min] |
3.1 [2.9–4.0] 1388 [1303–1553] 182 [156–229] 8.2 [6.6–9.0] 40 [29–62] 25 [23–28] |
3.2 [3.0–3.6] 1567 [1292–1664] 190 [172–225] 8.1 [6.8–8.5] 44 [32–56] 25 [24–26] |
3.1 [2.8–3.6] 1381 [1173–1502] 182 [144–221] 7.7 [7.2–8.2] 40 [28–56] 25 [23–26] |
0.223 0.067 0.316 0.974 0.601 0.368 |
- b - b - b - b - b - b |