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. 2023 Jan 10;15(1):238. doi: 10.3390/pharmaceutics15010238

Figure 2.

Figure 2

Figure 2

Representative pseudo-color plots showing the tri-variate analysis of CD40 vs. CD86 markers with characterization of HLA-DR expression using heatmap analysis of human whole blood samples stimulated with adjuvants (AS03, SEA S44, and SEA160) with media-treated and ex vivo stained samples as negative controls. AS03, SEA S44, and SEA160-stimulated whole blood samples showed an increase in CD40, CD86, and HLA-DR markers compared to media-treated samples in monocytes (a), mDC (b), and neutrophils (c), indicating induction of an antigen-presentation role.