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. 2023 Jan 10;15(1):238. doi: 10.3390/pharmaceutics15010238

Figure 3.

Figure 3

(a) Neutralizing antibody titers in serum obtained three weeks post-1st, 2nd and 3rd immunization against the CMV TB40 strain of virus. Each bar represents geometric mean titers (GMT) with 95% confidence interval (CI) from n = 10 animals per group. Statistical analysis was performed using one-way ANOVA followed by Tukey’s test to compare all groups with each other followed by Dunnett’s multiple comparisons test to compare each group with SE-AS44. Significant differences are marked on the graph only for 3wp2 titers. Comparison with CMV alone is shown in blue, with AS03 is shown in red, and with SEA160 is shown in green; ns = not significant, ** = p ˂ 0.005, *** = p ˂ 0.0005 . (b) Anti-CMV Penta IgG antibody titers in serum obtained three weeks post-1st, 2nd and 3rd immunization against the CMV TB40 strain of virus. Each bar represents geometric mean titers (GMT) with 95% confidence interval (CI) from n = 10 animals per group. Statistical analysis was performed using one-way ANOVA followed by Dunnett’s multiple comparisons test to compare differences between each group with SE-AS44. Significant differences are marked on the graph. Comparison with CMV alone is shown in blue, with AS03 is shown in red and with SEA160 is shown in green; ns = not significant, * = p ˂ 0.05, *** = p ˂ 0.0005.