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. 2023 Jan 21;13:1215. doi: 10.1038/s41598-023-27782-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Two R402H Tuba1a mouse lines expressing either wild-type or a modified version of exon 4. (a) Schematic representation of the genomic locus in both R402H Tuba1a conditional mouse lines. In both cases, exon 4 was flanked by LoxP sites to enable the expression of R402H mutant Tuba1a, in the presence of Cre recombinase. In the R402H Tuba1a (modified) line, the codon sequence was altered (in grey). This modification results in a different mRNA sequence compared to the R402H Tuba1a (wt) line however, on the protein level, both TUBA1A molecules share the same sequence. (b) Sequencing traces from the R402H Tuba1a (wt) and R402H Tuba1a (modified) lines show the synonymous variations introduced (gold stars).