Fig. 4. Effect of bilateral adrenalectomy.

a A schematic diagram of the experiment that bilateral adrenalectomy (ADx) performed on Day 1 and sacrifice death on Day 8. b Relative mRNA accumulation of Bmal1, Per2, and Rev-erbα in the liver and bladder from sham (solid line) and ADx (dash line). Each data series represents the mean ± SEM and 5 mice per time point. Differences were determined by two-way ANOVA and Sidak’s multiple comparisons test. *p < 0.01 v.s. sham.