Table 3.

Top ten transcription factors enriched in differentially expressed target genes.

Regulon	Transcription factor enrichment			Differential expression
	Evidence level	Female predicted activity	Male predicted activity	Females			Males
				Cst	LFC	FDR	Cst	LFC	FDR
NFKB1	A	−2.06	6.60	0.81	0.25	4.48e−01	0.87	0.42	6.18e−03
RELA	A	−1.16	6.01	0.88	0.29	9.00e−01	0.89	0.44	4.85e−01
STAT3	A	−1.30	5.73	0.85	−0.29	1	0.63	0.41	1.83e−01
STAT1	A	0.58	6.83	0.70	−0.42	6.93e−01	0.73	−0.43	4.09e−01
POU2F2	C	−2.02	4.19	0.62	0.13	1	0.59	0.36	1
CEBPA	A	−1.56	4.59	1.00	0.42	8.80e−01	0.52	0.41	8.43e−01
FOXO4	A	−2.49	2.62	0.55	0.51	6.82e−02	0.88	0.41	2.58e−01
KLF6	C	0.68	5.67	0.55	0.09	1	0.89	0.33	1.52e−01
RELB	C	−0.49	4.49	0.72	−0.28	1	0.89	0.30	9.08e−01
BATF	C	−1.60	3.36	0.91	−0.46	1	0.74	0.54	4.67e−01

The columns contain the results of the enrichment analysis (left) and the differential expression analysis (right). Functional annotations associated with these genes are found in Supplementary Table 9. The Omnipath/Dorothea evidence levels A, B, and C, respectively, represent high, likely, and medium confidences, see Figure 5A in ref. ¹⁵⁵ for more details.

Cst Consistency score, LFC log. fold change, FDR false discovery rate.