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. Author manuscript; available in PMC: 2023 Feb 4.
Published in final edited form as: J Nephrol. 2022 Jul 22;36(1):83–91. doi: 10.1007/s40620-022-01361-6

Fig. 2.

Fig. 2

Tryptophan/kynurenine pathway and changes in plasma concentrations of kynurenines in ADPKD patients versus healthy subjects. Dark blue arrows (up or down for concentration increase or decrease as compared to healthy age-matched subjects) represent changes observed in children and adults with ADPKD; light blue arrows represent change only seen in adults and light grey only in children; other colors such as for the increase of IDO1 (indoleamine 2,3-dioxygenase) expression and the decline of nicotinamide indicate hypothetical changes. Abbreviations: 3HAO 3-hydroxyanthranilate dioxygenase; IDO indoleamine 2,3-dioxygenase; KAT kynurenine transaminase; KFO kynurenine formylase; KMO kynurenine monooxygenase; KYNU kynureninase; NAD+ nicotinamide adenine dinucleotide; QPRT quinolinate phosphoribosyl transferase; TDO tryptophan 2,3-dioxygenase