Table 1.
Subject characteristics: healthy children and adults versus patients with ADPKD
| Healthy children (N = 50) | ADPKD children (N = 64) | Healthy adults (N = 66) | ADPKD adults (N = 38) Study A | ADPKD adults (N = 42) Study B | |
|---|---|---|---|---|---|
| Gender | 21 M, 29F | 26 M, 38F | 50 M, 16F | 26 M, 12F | 26 M, 18F |
| Age [years] | 11.8 ± 4.2 | 15.5 ± 3.6 | 51.0 [41.0, 57.3] | 36.4*** [30.0, 45.1] | 47.8*** [42.4, 56.8] |
| BMI [kg/m2] | – | 22.7 ± 4.6 | – | 26.1 [23.3, 30.0] | 25.4 [23.4, 29.8] |
| eGFR [mL/min/1.73m2] | Above 90 | 142 ± 38.1 | Above 90 | 94.0 [75.4, 106] | 52.5### [44.6, 58.6] |
| HtTKV [mL/m] | – | 280 [214, 373] | – | 530 [403, 871] | – |
| UAE [mg/24 h] | – | 26.9 [14.8, 46.5] | – | 22.4 [14.8, 33.7] | 25.6 [15.6, 42.8] |
| SBP [mm Hg] | – | 122 ± 10.7 | – | 123 [117, 132] | 126 [121, 136] |
| LVMI [g/m2] | – | 51.1 [45.7, 57.2] | – | 57.6 [49.1, 65.5] | – |
Data are presented as means ± standard deviations for normally distributed variables and as medians with 25th and 75th percentiles (interquartile ranges) for skewed variables. Study A enrolled individuals aged 15 to 49 diagnosed with ADPKD and a GFR of > 60 mL/min/1.73 m2. Study B enrolled individuals aged 18 to 64 diagnosed with ADPKD and a GFR in the range of 25–60 mL/min/1.73 m2
Significance levels were determined by one-way ANOVA with Tukey’s post-hoc: *p < 0.05, **p < 0.01, ***p < 0.001, and ###p < 0.001 for ADPKD patients with eGFR above or below 60 mL/min/1.73m2, respectively
BMI body mass index; eGFR estimated glomerular filtration rate, HtTKV height-corrected total kidney volume, LVMI left-ventricular mass index; UAE urinary albumin excretion; SBP systolic blood pressure