Table 2.
Performance of signatures in the discovery cohort and validation cohort 1.
| Sig | # | Discovery cohort - detection set |
Discovery cohort - replication set |
Validation cohort 1 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC | BPse | BPsp | BPt | AUC | BPse | BPsp | BPt | AUC | BPse | BPsp | BPt | ||
| 1 | 82 | 0.97 (0.94–1.00) | 0.96 (0.91–1.00) | 0.94 (0.88–0.98) | 0.42 | 0.99 (0.98–1.00) | 0.96 (0.91–1.00) | 0.96 (0.9–1.00) | 0.58 | 0.96 (0.94–0.98) | 0.94 (0.89–0.98) | 0.87 (0.84–0.92) | 0.42 |
| 2 | 61 | 0.98 (0.97–0.99) | 0.98 (0.91–1.00) | 0.92 (0.88–0.98) | 0.34 | 0.99 (0.98–1.00) | 0.96 (0.91–1.00) | 0.95 (0.89–1.00) | 0.55 | 0.97 (0.95–0.98) | 0.94 (0.88–0.98) | 0.88 (0.85–0.94) | 0.45 |
| 3 | 43 | 0.98 (0.97–1.00) | 0.98 (0.91–1.00) | 0.94 (0.9–1.00) | 0.35 | 0.99 (0.98–1.00) | 0.96 (0.91–1.00) | 0.95 (0.89–1.00) | 0.5 | 0.97 (0.95–0.98) | 0.92 (0.87–0.98) | 0.92 (0.85–0.96) | 0.58 |
| 4 | 37 | 0.98 (0.95–1.00) | 0.98 (0.93–1.00) | 0.96 (0.92–1.00) | 0.4 | 0.99 (0.98–1.00) | 0.96 (0.91–1.00) | 0.95 (0.89–1.00) | 0.5 | 0.97 (0.96–0.98) | 0.91 (0.88–0.99) | 0.93 (0.85–0.96) | 0.61 |
| 5 | 32 | 0.98 (0.96–1.00) | 0.98 (0.93–1.00) | 0.97 (0.94–1.00) | 0.38 | 0.99 (0.98–1.00) | 0.96 (0.91–1.00) | 0.95 (0.89–1.00) | 0.49 | 0.97 (0.96–0.99) | 0.92 (0.87–0.99) | 0.93 (0.86–0.97) | 0.59 |
| 6 | 27 | 0.99 (0.98–1.00) | 0.96 (0.93–1.00) | 0.97 (0.92–1.00) | 0.46 | 0.99 (0.98–1.00) | 0.96 (0.91–1.00) | 0.95 (0.89–1.00) | 0.55 | 0.97 (0.95–0.98) | 0.95 (0.89–0.99) | 0.88 (0.85–0.95) | 0.47 |
| 7 | 23 | 0.98 (0.95–1.00) | 0.98 (0.93–1.00) | 0.96 (0.91–1.00) | 0.42 | 0.98 (0.97–0.99) | 0.96 (0.91–1.00) | 0.95 (0.89–1.00) | 0.58 | 0.96 (0.95–0.98) | 0.93 (0.85–0.98) | 0.88 (0.83–0.95) | 0.48 |
| 8 | 19 | 0.99 (0.97–1.00) | 0.98 (0.93–1.00) | 0.95 (0.91–1.00) | 0.36 | 0.98 (0.97–0.99) | 0.96 (0.91–1.00) | 0.95 (0.89–0.98) | 0.6 | 0.96 (0.95–0.98) | 0.92 (0.84–0.97) | 0.91 (0.85–0.97) | 0.58 |
| 9 | 18 | 0.98 (0.97–1.00) | 0.96 (0.93–1.00) | 0.96 (0.91–1.00) | 0.47 | 0.98 (0.97–0.99) | 0.96 (0.9–1.00) | 0.93 (0.89–1.00) | 0.56 | 0.97 (0.95–0.98) | 0.89 (0.84–0.97) | 0.93 (0.86–0.97) | 0.63 |
| 10 | 15 | 0.98 (0.97–1.00) | 1 (0.98–1.00) | 0.95 (0.9–0.98) | 0.36 | 0.98 (0.97–0.99) | 0.96 (0.91–1.00) | 0.93 (0.89–0.98) | 0.46 | 0.96 (0.95–0.98) | 0.9 (0.84–0.96) | 0.92 (0.87–0.97) | 0.59 |
| 11 | 12 | 0.98 (0.94–1.00) | 0.95 (0.91–1.00) | 0.98 (0.92–1.00) | 0.56 | 0.98 (0.97–0.99) | 0.96 (0.91–1.00) | 0.93 (0.89–0.98) | 0.47 | 0.96 (0.94–0.98) | 0.9 (0.84–0.97) | 0.89 (0.83–0.96) | 0.48 |
| 12 | 9 | 0.99 (0.99–1.00) | 1 (0.95–1.00) | 0.95 (0.91–1.00) | 0.4 | 0.98 (0.97–0.99) | 0.95 (0.88–1.00) | 0.93 (0.86–0.98) | 0.54 | 0.96 (0.94–0.97) | 0.89 (0.83–0.96) | 0.9 (0.82–0.95) | 0.47 |
| 15 | 6 | 0.99 (0.98–1.00) | 1 (0.93–1.00) | 0.92 (0.88–1.00) | 0.36 | 0.98 (0.97–1.00) | 0.98 (0.93–1.00) | 0.92 (0.87–1.00) | 0.33 | 0.95 (0.93–0.97) | 0.9 (0.84–0.98) | 0.88 (0.8–0.94) | 0.49 |
| 18 | 5 | 0.99 (0.98–1.00) | 0.96 (0.95–1.00) | 0.95 (0.88–0.98) | 0.44 | 0.98 (0.96–1.00) | 0.98 (0.93–1.00) | 0.93 (0.89–0.98) | 0.42 | 0.94 (0.92–0.96) | 0.92 (0.82–0.97) | 0.83 (0.79–0.94) | 0.4 |
| 19 | 4 | 0.99 (0.98–1.00) | 0.95 (0.91–1.00) | 0.97 (0.91–1.00) | 0.49 | 0.98 (0.97–1.00) | 0.98 (0.91–1.00) | 0.92 (0.87–1.00) | 0.41 | 0.94 (0.91–0.96) | 0.92 (0.81–0.95) | 0.84 (0.81–0.93) | 0.42 |
| 20 | 2 | 0.96 (0.92–0.99) | 0.98 (0.86–1.00) | 0.86 (0.82–0.97) | 0.29 | 0.97 (0.95–0.99) | 0.96 (0.91–1.00) | 0.9 (0.83–0.97) | 0.4 | 0.94 (0.91–0.96) | 0.91 (0.8–0.95) | 0.85 (0.81–0.95) | 0.4 |
| CA 19-9 |
0.94 (0.9-0.98) | 0.78 (0.73–0.96) | 0.97 (0.82–1.00) | 0.48 | 0.92 (0.87–0.96) | 0.85 (0.72–0.95) | 0.87 (0.79–0.98) | 0.41 | 0.9 (0.87–0.94) | 0.73 (0.66–0.97) | 0.93 (0.66–0.97) | 0.57 | |
All values are presented with bootstrapped 95% CIs in parentheses.
AUC, area under receiver-operating characteristic curve; BPse, best point sensitivity; BPsp, best point specificity; BPt, best point threshold; CA19-9, carbohydrate antigen 19-9; Sig, signature.
#
Number of proteins.