Table 3.

Performance of the signatures in validation cohort 2.

Sig	#	Blinded prediction			Unblinded prediction
		Sensitivity	Specificity	Threshold	AUC	BPse	BPsp	BPt
1	82	1.00	0.71	0.58	0.92 (0.86-0.97)	1.00 (1.00-1.00)	0.82 (0.76-0.94)	0.90
2	61	1.00	0.68	0.55	0.93 (0.88-0.98)	1.00 (1.00-1.00)	0.85 (0.79-0.95)	0.92
3	43	1.00	0.64	0.5	0.93 (0.88-0.98)	1.00 (0.87-1.00)	0.82 (0.76-0.96)	0.88
4	37	1.00	0.61	0.5	0.93 (0.87-0.98)	1.00 (0.87-1.00)	0.80 (0.75-0.95)	0.85
5	32	1.00	0.62	0.49	0.92 (0.87-0.98)	1.00 (0.87-1.00)	0.79 (0.74-0.94)	0.82
6	27	1.00	0.65	0.55	0.94 (0.89-0.98)	1.00 (1.00-1.00)	0.84 (0.79-0.96)	0.88
7	23	1.00	0.69	0.58	0.93 (0.88-0.98)	1.00 (1.00-1.00)	0.83 (0.78-0.94)	0.89
8	19	1.00	0.69	0.6	0.91 (0.86-0.97)	1.00 (1.00-1.00)	0.83 (0.77-0.91)	0.89
9	18	1.00	0.68	0.56	0.91 (0.85-0.96)	1.00 (1.00-1.00)	0.84 (0.78-0.91)	0.89
10	15	1.00	0.64	0.46	0.91 (0.85-0.96)	1.00 (1.00-1.00)	0.84 (0.78-0.91)	0.87
11	12	1.00	0.65	0.47	0.87 (0.80-0.95)	1.00 (0.87-1.00)	0.70 (0.65-0.89)	0.68
12	9	1.00	0.67	0.54	0.87 (0.78-0.95)	1.00 (1.00-1.00)	0.74 (0.67-0.90)	0.69
15	6	1.00	0.48	0.33	0.84 (0.75-0.94)	1.00 (0.87-1.00)	0.64 (0.58-0.89)	0.51
18	5	1.00	0.58	0.42	0.85 (0.76-0.94)	1.00 (0.87-1.00)	0.67 (0.61-0.85)	0.52
19	4	0.88	0.53	0.41	0.85 (0.74-0.96)	0.87 (0.75-1.00)	0.82 (0.50-0.90)	0.74
20	2	1.00	0.52	0.4	0.84 (0.72-0.95)	1.00 (0.75-1.00)	0.61 (0.54-0.94)	0.49
CA19-9		0.88	0.44	0.41	0.73 (0.50-0.95)	0.75 (0.37-1.00)	0.68 (0.45-1.00)	0.59

All values are presented with bootstrapped 95% CIs in parentheses.

AUC, area under receiver-operating characteristic curve; BPse, best point sensitivity; BPsp, best point specificity; BPt, best point threshold; CA19-9, carbohydrate antigen 19-9; Sig., signature.

^#Number of proteins.