Table 2.
Univariate and multivariate Cox proportional hazard regression model showing the effect of demographic and clinical variables on the events
| Variables | Univariate analyses | Multivariate analyses | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age | 1.00 (0.98–2.31) | 0.878 | 1.79 (0.70–2.02) | 0.576 |
| Gender (Male) | 1.11 (1.01–1.68) | 0.634 | 1.70(0.9–2.30) | 0.40 |
| Haemoglobin (< 10 g/dL) | 1.53 (0.72–2.83) | < 0.001 | 1.08 (0.72–1.83) | 0.356 |
| ALC (× 109/L) (< 50) | 1.10 (0.76–1.30) | 0.20 | 1.72 (0.67–2.06) | 0.17 |
| Platelet Count (× 109/L) (< 150) | 1.05 (0.51–1.62) | 0.10 | 0.68 (0.51–0.92) | 0.13 |
| ZAP70 (> 20%) | 1.21(0.71–2.1) | 0.38 | 1.11 (0.79–1.84) | 0.387 |
| CD38 (> 20%) | 1.36(0.94–1.97) | 0.10 | 2.36(0.94–4.97) | 0.105 |
| CD49d (> 30%) | 1.66(1.14–2.40) | 0.08 | 1.44(0.75–2.40) | 0.13 |
| Beta-2 microglobulin (≥ 3.5 mg/L) | 2.96 (1.23–7.2) | 0.015 | 1.26 (0.64–2.47) | 0.497 |
| Unmutated IGHV status | 4.5 (2.55–8.06) | 0.01 | 3.6 (1.10–9.2) | 0.001 |
ALC Absolute lymphocyte count, ZAP70 Zeta-chain associated protein kinase-70 (positivity cut-off 20%), CD Cluster of differentiation, IGHV Immunoglobulin heavy chain variable region
*CD38 positivity cut-off > 20%, ^CD49d positivity cut-off > 30%