Table 2:
Changes in Mean Scores of HCV-PRO Items Over 24 Weeks
| HCV-PRO Item | Change in Mean from Day 0 to Week 12 |
P Value | Change in Mean from Day 0 to Week 24 |
P Value | Change in Mean from Week 12 to Week 24 |
P Value |
|---|---|---|---|---|---|---|
| I felt too tired during the day to get done what I needed | +0.50 | <0.001 | +0.58 | <0.001 | +0.01 | 0.907 |
| I needed to pace myself to finish what I had planned | +0.26 | 0.035 | +0.27 | 0.030 | −0.01 | 0.918 |
| I felt forced to spend time in bed | +0.05 | 0.661 | +0.25 | 0.028 | +0.23 | 0.045 |
| My muscles felt weak | +0.49 | <0.001 | +0.39 | <0.001 | −0.05 | 0.669 |
| I could not get comfortable during the day | +0.48 | <0.001 | +0.67 | <0.001 | +0.14 | 0.211 |
| I was unable to think clearly or focus on my thoughts | +0.49 | <0.001 | +0.43 | <0.001 | −0.03 | 0.776 |
| I was forgetful | +0.26 | 0.024 | +0.33 | 0.002 | −0.03 | 0.815 |
| Having hepatitis C affected my sex life | +0.06 | 0.631 | +0.12 | 0.321 | +0.05 | 0.617 |
| I felt bothered by pain or physical discomfort | 0.13 | 0.283 | +0.18 | 0.175 | 0.12 | 0.420 |
| I found it hard to meet people or make new friends because of my hepatitis C | +0.20 | 0.004 | +0.12 | 0.105 | −0.03 | 0.629 |
| Having hepatitis C was very stressful to me | +0.59 | <0.001 | +0.58 | <0.001 | −0.08 | 0.474 |
| I felt downhearted and sad | +0.49 | <0.001 | +0.50 | <0.001 | +0.03 | 0.829 |
| I felt restless or on edge | +0.25 | 0.022 | +0.29 | 0.014 | +0.09 | 0.394 |
| I felt little interest in doing things | +0.29 | 0.011 | +0.31 | 0.008 | +0.03 | 0.785 |
| I had difficulty sleeping or slept too much | +0.31 | 0.024 | +0.38 | 0.004 | +0.09 | 0.550 |
| Hepatitis C lowered my quality of life | +0.44 | <0.001 | +0.39 | 0.001 | −0.03 | 0.769 |