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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: Biomaterials. 2022 Dec 24;293:121960. doi: 10.1016/j.biomaterials.2022.121960

Figure 3. Regional COPD Human Lung ECM Composition.

Figure 3.

wECM, airECM, aECM, and vECM samples were obtained from three individual COPD human lungs for proteomic analysis (n=3). (A) Schematic depicting samples utilized for proteomic analysis. (B) PCA plot demonstrating similarity of ECM protein composition amongst region-specific samples. Each data point represents the relative abundance (%) of all individual ECM proteins (normalized to abundance of total ECM composition within each respective sample).(C) Heatmap of top 25 normalized ECM proteins across all decellularized lung regions. (D) Ratio of mean basement membrane composition from decellularized lung specific regions. (E) Comparison of normalized individual ECM proteins across lung regions. Bars indicate mean +/− SEM, n=3 biological replicates; *p<0.05, **p<0.01 using Dunn’s method. Statistical trends are identified if 0.05≤p<0.1. (F) Qualitative Venn diagram depicting differences in region-specific ECM composition of pooled samples.