TABLE 1.
Main laboratory data.
| Variables | Normal values |
On admission | Day 15 |
Day 22 Eculizumab ➀ |
Day 29 Eculizumab ➁ |
Day 36 |
| Hematology tests | ||||||
| White blood cells (/μL) | 3,300–8,600 | 140,00 | 31,00 | 26,00 | 46,00 | 45,00 |
| Lymphocytes (/μL) | 1,100–3,200 | 434 | 465 | 260 | 938 | 990 |
| Hemoglobin (g/dL) | 11.6–14.8 | 13.8 | 7.3 | 7.7 | 8.2 | 9.0 |
| Platelets (/μL) | 158,000–348,000 | 172,000 | 66,000 | 68,000 | 240,000 | 327,000 |
| Schistocytes (/HPF) | Negative | Negative | 16 | 14 | 14 | Negative |
| Creatinine (mg/dL) | 0.46–0.79 | 0.78 | 0.58 | 0.62 | 0.57 | 0.73 |
| AST (U/L) | 13–30 | 118 | 80 | 153 | 77 | 41 |
| ALT (U/L) | 10–42 | 209 | 70 | 100 | 168 | 74 |
| LDH (U/L) | 124–222 | 538 | 702 | 912 | 407 | 318 |
| C-reactive protein (mg/dL) | 0.0–0.14 | 8.59 | 15.11 | 15.13 | 2.34 | 1.85 |
| Ferritin (ng/mL) | 31–325 | 11,460 | 45,760 | 56,740 | 1,843 | 1,039 |
| PT-INR | 0.8–1.2 | 1.18 | 1.03 | 1.07 | 1.04 | 1.08 |
| APTT (s) (reference) | 24.4–39.2 | 29.0 (26.7) | 29.1 (26.9) | 27.5 (26.9) | 32.0 (26.9) | 33.7 (26.9) |
| Fibrinogen (mg/dL) | 190–330 | 699 | 292 | 162 | 200 | 289 |
| D-dimer (μg/dL) | 0–1 | 9.0 | 11.87 | 4.53 | 2.61 | 1.02 |
| C3 (mg/dL) | 86–160 | 83 | 73 | 64 | 83 | 89 |
| C4 (mg/dL) | 17–45 | 23.5 | 17.1 | 12.2 | 29.4 | 31.9 |
| CH50 (U/mL) | 30–40 | 43.8 | 31 | 31.9 | 10.8 | 11.7 |
| ANA | <40 | 160 (speckle) | ||||
| Anti-dsDNA antibody (U/L) | <12 | <10 | ||||
| Anti-DNA antibody (U/L) | <6.0 | <1.7 | ||||
| Anti-Sm antibody (U/mL) | <10 | 31.9 | ||||
| Anti-RNP antibody (U/mL) | <10 | 32.2 | ||||
| Anti-SS-A antibody (U/mL) | <10 | 80.6 | ||||
| Anti-cardiolipin antibody, IgG | <10 | 2 | ||||
| Anti-β2 glycoprotein I | <3.5 | <1.3 | ||||
| Lupus anticoagulant (dRVVT) | 1.2 | 1.00 | ||||
| ADAMTS13 activity (%) | 35 | 35 | ||||
| Inhibitor of ADAMTS13 | Negative | |||||
| Urinalysis | ||||||
| Red blood cells (/HPF) | <4 | <4 | <4 | <4 | <4 | |
| White blood cells (/HPF) | 5–9 | <4 | <4 | <4 | <4 | |
| Urinary protein (g/gCr) | 0.12 | 0.74 | 1.10 | 0.10 | 0.12 | |
ALT, Alanine transaminase; ANA, Antinuclear antibody; ANCA, Anti-neutrophil cytoplasmic antibody; APTT, Activated partial thromboplastin time; AST, Aspartate transaminase; dRVVT, diluted Russell viper venom time; HPF, High-power field; LDH, Lactate dehydrogenase; MPO, Myeloperoxidase; PT, Prothrombin time; PR3, Proteinase3; HPF, high-power field.