TABLE 5.

Additional treatments for steroids-refractory immune-mediated hepatitis from case reports.

Additional treatments	Time for recovery of liver parameters	Ref
MMF 1 g/day for 1 week plus ATG 1.5 mg/kg/day for 2 consecutive days	1 month from the start of the ATG	Chmiel et al. (2011)
MMF 500 mg twice-daily plus intravenous ATG 1.5 mg/kg/day for 2 consecutive days	After 49 days	Motomura et al. (2020)
MMF 1 g/day plus two intravenous doses of ATG of 100 and 50 mg for 2 consecutive days	After 162 days	McGuire et al. (2018)
MMF 1 g twice daily for 2 weeks plus ATG for 2 dosages	After 2 eeks	Ahmed et al. (2015)
ATG 100 mg/day	After 5 days	Spankuch et al. (2017)
MMF 500 mg plus tacrolimus 500 mg twice daily	After 186 days	McIlwaine et al. (2022)
MMF 1 g twice daily plus tacrolimus 5 mg/kg/day	N/A	Cheung et al. (2019)
MMF 1 g plus tacrolimus 1.5 mg/kg twice daily	After 9 weeks	Ziogas et al. (2020)
Cyclosporine 100 mg twice daily	After 40 days	Huffman et al. (2018)
Oral AZA with 100 mg/day	After 1 month	Iwamoto et al. (2017)
UDCA 600 mg/day plus bezafibrate 400 mg/day	After 35 days	Onishi et al. (2020)
Oral MMF 2 g/day plus UDCA	After 56 days	Doherty et al. (2017)
MMF 1.5 g/day plus plasma exchange (1,500 ml of 5% albumin plus 4 units of plasma, every other day)	After 2 weeks	Riveiro-Barciela et al. (2019)

MMF, mycophenolate mofetil; ATG, anti-thymocyte globulin; AZA, azathioprine; UDCA, ursodeoxycholic acid.