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. 2023 Jan 9;10:1091629. doi: 10.3389/fcell.2022.1091629

FIGURE 7.

FIGURE 7

Defects in neural plate and somitic mesoderm morphogenesis have additive impact on neural tube closure. (A) Dorsal views of representative Control, Vangl2 morphant, Wee2 morphant and Vangl2/Wee2 double morphant embryos. Blue outline: neural plate. Double headed arrow: neural plate width. Scale bars: 100 μm. Control and morphant embryos are siblings raised side by side (B) Quantification of neural plate width in Control, Vangl2 morphant, Wee2 and Vangl2/Wee2 double morphant embryos. Neural tube closure is severely affected in Vangl2/Wee2 double morphant embryos. One-way Anova; ns: no significant; ****p < .0001; mean ± SEM n = 9 embryos. (C) Dorsal views of representative Control, Shroom3 morphant, Wee2 morphant and Shroom3/Wee2 double morphant embryos. Blue outline: neural plate. Double headed arrow: neural plate width. Scale bars: 100 μm. Control and morphant embryos are siblings raised side by side (D) Quantification of neural plate width in Control, Shroom3 morphant, Wee2 morphant and Shroom3/Wee2 double morphant embryos. Neural tube closure is severely affected in Shroom3/Wee2 double morphant embryos. One-way Anova; ns: no significant; *p = .106: ****p < .0001; mean ± SEM n = 11 control, 9 Shroom3 and Wee2 morphant and 10 Wee2/Shroom3 double morphant embryos.