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. 2023 Jan 9;13:1079455. doi: 10.3389/fgene.2022.1079455

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Copyright © 2023 Xu, Yu, Zhou, Wu, Deng, Wu, Wang, Gao, Nie, Zhou, Sun and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Significant association between GSTA4 mRNA expression and DNA methylation. (A) mRNA expression levels in the IA group were higher than that in controls. (B) mRNA expression levels in women IAs were higher than that in women controls. (C) No statistical significance was observed between men IAs and men controls. (D) GSTA4 mRNA expression was correlated with its DNA methylation levels in all participants. (E) DNA hypomethylation induced by AZA increased the mRNA expression of the GSTA4 gene in HBVSMCs. (F,G) GSTA4 methylation levels in between smoker and non-smoker group. (H) GSTA4 mRNA expression between smoker and non-smoker groups.