TABLE 5.
The gender differences in DNA methylation of nine CpGs of GSTA4 gene in IAs and controls respectively.
| Character | Men | Women | t | p |
|---|---|---|---|---|
| All | (n = 44) | (n = 44) | ||
| CpG1 (%) | 11.57 ± 3.06 | 11.61 ± 4.11 | .05 | .962 |
| CpG2 (%) | 8.35 ± 2.96 | 9.92 ± 3.91 | 2.12 | .037 |
| CpG3 (%) | 5.83 ± 1.91 | 6.78 ± 2.23 | 2.15 | .034 |
| CpG4 (%) | 5.54 ± 1.74 | 6.29 ± 2.30 | 1.72 | .090 |
| CpG5 (%) | 10.16 ± 3.05 | 10.95 ± 3.78 | 1.07 | .287 |
| CpG6 (%) | 4.82 ± 1.26 | 5.41 ± 1.80 | 1.79 | .078 |
| CpG7 (%) | 6.35 ± 1.65 | 6.99 ± 1.96 | 1.66 | .100 |
| CpG8 (%) | 6.26 ± 1.45 | 7.05 ± 1.70 | 2.35 | .021 |
| CpG9 (%) | 6.04 ± 1.68 | 6.60 ± 1.72 | 1.56 | .121 |
| Mean (%) | 7.21 ± 1.86 | 7.96 ± 2.27 | 1.68 | .096 |
| IA | (n = 22) | (n = 22) | ||
| CpG1 (%) | 11.64 ± 3.47 | 9.03 ± 3.19 | 2.61 | .013 |
| CpG2 (%) | 7.68 ± 2.25 | 8.31 ± 3.55 | .7 | .487 |
| CpG3 (%) | 5.27 ± 1.22 | 5.71 ± 1.49 | 1.06 | .297 |
| CpG4 (%) | 5.07 ± 1.19 | 5.11 ± 1.35 | .09 | .925 |
| CpG5 (%) | 9.78 ± 3.09 | 9.69 ± 3.36 | .08 | .935 |
| CpG6 (%) | 4.48 ± .94 | 4.61 ± 1.43 | .34 | .735 |
| CpG7 (%) | 5.93 ± .95 | 6.16 ± 1.59 | .58 | .561 |
| CpG8 (%) | 5.83 ± 1.06 | 6.28 ± 1.23 | 1.31 | .199 |
| CpG9 (%) | 6.07 ± 1.16 | 5.80 ± 1.34 | .702 | .487 |
| Mean (%) | 6.86 ± 1.53 | 6.74 ± 1.55 | .25 | .803 |
| Control | (n = 22) | (n = 22) | ||
| CpG1 (%) | 11.50 ± 2.66 | 14.19 ± 3.24 | 3 | .004 |
| CpG2 (%) | 9.02 ± 3.45 | 11.53 ± 3.65 | 2.35 | .024 |
| CpG3 (%) | 6.39 ± 2.31 | 7.86 ± 2.35 | 2.1 | .042 |
| CpG4 (%) | 6.00 ± 2.08 | 7.46 ± 2.47 | 2.11 | .041 |
| CpG5 (%) | 10.55 ± 3.02 | 12.20 ± 3.83 | 1.59 | .121 |
| CpG6 (%) | 5.15 ± 1.47 | 6.21 ± 1.79 | 2.14 | .038 |
| CpG7 (%) | 6.77 ± 2.08 | 7.83 ± 1.97 | 1.73 | .091 |
| CpG8 (%) | 6.70 ± 1.67 | 7.83 ± 1.77 | 2.18 | .035 |
| CpG9 (%) | 6.01 ± 2.10 | 7.41 ± 1.71 | 2.42 | .020 |
| Mean (%) | 7.57 ± 2.11 | 9.17 ± 2.25 | 2.44 | .019 |
Abbreviation: GSTA4, Glutathione S-transferase alpha 4; IA, intracranial aneurysm; Data were presented as mean ± SD. The t-test was used for group comparison. The p-value less than or equal to .05 is in bold.