Table 3.
Clinical differences between predicted endotypes in the early sampled group.
| Parameter | NPS (17/76) | INF (16/76) | IHD (12/76) | IFN (14/76) | ADA (17/76) | p value |
|---|---|---|---|---|---|---|
| Respiratory support group—moderate | 5.9% (1/17) | 25% (4/16) | 91.7% (11/12) | 50.0% (7/14) | 35.3% (6/17) | 0.000075 |
| Receiving ICU care | 76.5% (13/17) | 62.5% (10/16) | 8.3% (1/12) | 14.3% (2/14) | 29.4% (5/17) | 0.00018 |
| Respiratory support group—severe | 76.5% (13/17) | 37.5% (6/16) | 8.3% (1/12) | 21.4% (3/14) | 29.4% (5/17) | 0.0015 |
| Glasgow coma score | 13.3 ± 1.71 (7) | 8 ± 2.86 (5) | 15 ± 0 (5) | 15 ± 0 (5) | 15 ± 0 (9) | 0.0174 |
| P/F ratio | 213.6 ± 19.82 (7) | 175.2 ± 29.91 (5) | 382.6 ± 21.36 (5) | 274.4 ± 58.3 (5) | 254.8 ± 31.26 (9) | 0.022 |
| qSOFA | 0.6 ± 0.3 (7) | 1.4 ± 0.4 (5) | 0 ± 0 (5) | 0.2 ± 0.2 (5) | 0.4 ± 0.18 (8) | 0.0454 |
The mean value ± standard error is presented for numerical variables with the total available observations/patient numbers recorded in brackets. Categorical variables are presented as % positive (relative to total available observations). Significance was assessed using a Kruskal–Wallis and Chi Square Test for numeric and categorical parameters, respectively. The P/F ratio is the arterial pO2 (“P”) divided by the FIO2 (“F”) with a P/F Ratio less than 300 indicating acute respiratory failure52. A full table of clinical parameters assessed, including non-significant parameters, is provided in Supplemental Table 2.