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. 2023 Jan 9;13:1037417. doi: 10.3389/fphys.2022.1037417

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Copyright © 2023 Chun, Aryal, Varughese, Sun, Bruno, Richards, Bachstetter and Kekenes-Huskey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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P2X and P2Y receptors can be combined to control different cellular outcomes. P2X4-induced Ca²⁺ entry manifests a sharp but brief rise in cytosolic Ca²⁺. P2X7-mediated Ca²⁺ entry results in blunt and prolonged Ca²⁺ elevations. P2Y-class receptors (mainly P2Y2) yield oscillatory Ca²⁺ transients, while P2Y12 (not shown) promotes membrane displacement.