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. 2023 Jan 9;13:1037417. doi: 10.3389/fphys.2022.1037417

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Copyright © 2023 Chun, Aryal, Varughese, Sun, Bruno, Richards, Bachstetter and Kekenes-Huskey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Predicted TNFα production (black dashed) and migration (black solid), normalized to control conditions (dashed box) in response to variations of the intracellular Ca²⁺ waveform frequency (A) and amplitude (B). All calculations were performed using 200 µM ATP and the data were collected over 5 min after ATP addition.