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. 2023 Jan 9;13:1037417. doi: 10.3389/fphys.2022.1037417

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Copyright © 2023 Chun, Aryal, Varughese, Sun, Bruno, Richards, Bachstetter and Kekenes-Huskey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Complete schematic of the computational model. (A) P2X4/7-mediated Ca²⁺ entry. (B) P2Y2-mediated Ca²⁺ transients. (C) Hydrolysis of ATP by ENTs (CD39). (D) P2Y12-mediated cell migration. (E) Ca²⁺-dependent downstream cascades associated with TNFα production.