FIGURE 2.

The effects of GSH pretreatment on the mPTP in heart of old rats. (A) Native curves of Ca²⁺-induced mitochondrial swelling. (B) Changes in the sensitivity of mPTP to calcium ions (10⁻⁷–10⁻⁴ mol L⁻¹) in the heart of adult, old and GHS pretreated old rats: the ordinate axis shows the difference between the observed amplitude of swelling of mitochondrial swelling on the 15th min and the optical density of suspension on the 1st min. The dashed line shows the swelling of the adult mitochondria in Ca²⁺-free and Ca²⁺-contained mediums. GSH, glutathione. Data are represented as mean ± SEM; n = 7–9. *р < 0.05 versus adult; ^# р < 0.05 versus old as calculated by ANOVA test.