TABLE 2.
Comparison of patients with and without a history of pneumococcal vaccination at baseline.
| Variable | Pneumococcal vaccine (−) | Pneumococcal vaccine (+) | P-value |
| n = 1,111 | n = 586 | ||
| Female, n (%) | 885 (80.1%) | 473 (81%) | 0.66 |
| Age, years, mean (SD) | 60.4 (13.1) | 64.0 (11.2) | <0.001 |
| Disease duration, years, mean (SD) | 8.5 (8.5) | 12.2 (8.9) | <0.001 |
| Early disease (<2 years), n (%) | 249 (22.4%) | 60 (10.2%) | <0.001 |
| RF and/or anti-CCP+, n (%) | 518 (49.4%) | 319 (56.5%) | 0.007 |
| Erosions, n (%) | 306 (38.2%) | 249 (57.2%) | <0.001 |
| Working, n (%) | 343 (35.1%) | 119 (21.4%) | <0.001 |
| Tertiary education, n (%) | 173 (19.9%) | 84 (16%) | 0.06 |
| DAS28-ESR, mean (SD) | 3.46 (1.36) | 3.29 (1.14) | 0.015 |
| HAQ, median (IQR) | 0.25 (0.75) | 0.25 (0.88) | 0.39 |
| Arthroplasties, n (%) | 105 (9.5%) | 66 (11.3%) | 0.24 |
| csDMARDs, n (%) | 935 (84.2%) | 476 (81.2%) | 0.12 |
| bDMARDs, n (%) | 412 (37.1%) | 347 (59.2%) | <0.001 |
| Glucocorticoids, n (%) | 374 (33.7%) | 222 (37.9%) | 0.08 |
| Glucocorticoids, mg/day, mean (SD) | 5.2 (2.7) | 4.5 (2.7) | 0.002 |
| Current smokers, n (%) | 188 (18.1%) | 92 (16.8%) | 0.49 |
| Alcohol use (>1 day/week) | 62 (5.9%) | 42 (7.6%) | 0.20 |
| Dyslipidemia, n (%) | 341 (30.7%) | 238 (40.6%) | <0.001 |
| Coronary artery disease, n (%) | 46 (4.1%) | 35 (6%) | 0.09 |
| Stroke, n (%) | 31 (2.8%) | 19 (3.2%) | 0.60 |
| Hypertension, n (%) | 444 (40%) | 280 (47.8%) | 0.002 |
| Diabetes, n (%) | 147 (13.2%) | 87 (14.8%) | 0.36 |
| COPD and/or RA-ILD, n (%) | 62 (5.6%) | 79 (13.5%) | <0.001 |
| Depression, n (%) | 122 (11%) | 84 (14.3%) | 0.04 |
| Osteoporosis, n (%) | 267 (24%) | 184 (31.4%) | 0.001 |
| Cancer (current/past), n (%) | 72 (6.5%) | 27 (4.6%) | 0.12 |
| History of hospitalization (last 12 months), n (%) | 78 (7%) | 54 (9.2%) | 0.11 |
| History of serious infection, n (%) | 69 (6.2%) | 89 (15.2%) | <0.001 |
| History of influenza vaccination, n (%) | 347 (31.2%) | 556 (94.9%) | <0.001 |
| BMI, kg/m2, mean (SD) | 27.2 (5.1) | 28.0 (5.4) | 0.005 |
| BMI > 30 kg/m2, n (%) | 221 (19.9%) | 164 (28%) | <0.001 |
| RDCI, median (IQR) | 0 (1) | 0 (1) | 0.001 |