Figure 2.

The eleven TCR-mimetic antibodies (TCRms) with solved structures in complex with their cognate pMHC, aligned by the MHC residues. The perspective is set so that the x-axis is the vector through the C_α atoms of the peptide anchor residues. 3M4E5 and 3M4F4 are closely related and derive from the same screening campaign, so are jointly represented by 3M4E5 in the analysis. Metadata is supplied below each structure: the TCRm name and Protein Data Bank (PDB) identifier, year of release in the PDB, MHC allele, antigen amino acid sequence, and antigen common name. ESK1 and H2 fall outside the range of diagonality seen in TCR:pMHC binding (PDB codes written in black). Diagonally-binding TCRms with VH in the position of VB and VL in the position of VA (canonical polarity binders) have blue PDB codes, while those with VH in the position of VA and VL in the position of VB (reverse polarity binders) have red PDB codes. CTA, cancer testis antigen; MHCA, MHC alpha chain; MHCB, MHC beta chain; Neo, neoantigen; NKA, natural killer cell antigen; TAA, tumor-associated antigen. *We have labelled the TCRm from 7RE7 as AFP-TCRm as it has no name in the seminal paper (29).