Figure 2.

Screening for the cytotoxicity and the anti-H₂O₂ activity of the evodiamine derivatives. (A, B) SH-SY5Y cells and HepaG2 cells were treated with Evo and Evo derivatives at concentrations of 1, 10, and 50 μg/ml for 24 h. The cytotoxicity of Evo and its derivatives was subsequently assessed by detecting cell viability using CCK8. (C) SH-SY5Y cells were co-incubated with 75 μM H₂O₂ and different concentrations of Evo derivatives (10⁻³, 10⁻², and 10⁻¹ μg/ml) for 24 h, and cell viability was quantified using CCK8. Data are represented as mean ± SEM, n = 6; ^*P < 0.05, ^**P < 0.01, and ^***P < 0.001 vs. control.