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. 2023 Jan 9;15:1025066. doi: 10.3389/fnmol.2022.1025066

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Copyright © 2023 Pang, Li, Cheng, Luo, Qi, Guan, Dong, Gao, Liu, Gao, Pan, Zhang, Zhang, Yang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome analysis of hippocampal tissues. Hippocampal tissues from 3 x Tg AD mice treated without or with 4c (i.e., 3 x Tg and 4c-H groups) were selected for transcriptome analysis. (A) Volcano plots of DEGs between the 3 x Tg and 4c-H groups. DEGs were identified by comparing 3 x Tg and 4c-H mice using fold change >1 and P-value <0.05 as the cut-off (n = 3). (B, C) Hierarchical clustering and PCA analysis of the 3 x Tg and 4c-H groups were performed using the normalized RNA-seq read counts. (D) KEGG pathways enriched in the 628 and 654 genes that were upregulated and downregulated, respectively, in 4c-H mice compared with the 3 x Tg mice (n = 3). (E–I) AD-related genes (Ide, Adam10, Caspase7, Snca, and Aph-1b) were detected by RT-qPCR and compared among the WT, 3 x Tg, and 4c-H groups (n = 5). Data are represented as mean ± SEM; ^*P < 0.05, ^**P < 0.01, and ^***P < 0.001.