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. 2023 Jan 9;15:1025066. doi: 10.3389/fnmol.2022.1025066

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Copyright © 2023 Pang, Li, Cheng, Luo, Qi, Guan, Dong, Gao, Liu, Gao, Pan, Zhang, Zhang, Yang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Compound 4c activates the PI3K/AKT/GSK3β signaling pathway. (A) Protein–protein interaction network involving the AMPK signaling pathway. Compound 4c affected the 19 proteins shown in red, and 25 interacting proteins identified by the STRING search are shown in blue. (B) Effects of 4c treatment on p-PI3K, p-AKT, and p-GSK-3β protein expression in 3 x Tg mice. (C–E) Relative protein abundance of p-PI3K/PI3K, p-AKT/AKT, and p-GSK3β/GSK3β in each group. Data are the mean ± SEM, n = 5; ^*P < 0.05 and ^**P < 0.01 as indicated in the figure.