Table 1.
Three grouping strategies tested with composite model
| Grouping strategy 1 |
Grouping strategy 2 |
Grouping strategy 3 |
|||
|---|---|---|---|---|---|
| Composite indices | Combo variables | Composite indices | Combo variables | Composite indices | Combo variables |
| White blood cell group | 1 PCT neutrophils | comp1 | 1 PCT neutrophils | comp1 | 1 PCT neutrophils |
| 5 PCT basophils | 2 ALT | 21 creatinine | |||
| 19 WBC | 4 AST | comp2 | 2 ALT COMBO | ||
| 22 PCT eosinophils | 6 bilirubin direct | 22 PCT eosinophils | |||
| 25 PCT monocytes | 7 bilirubin direct | 17 phosphorus | |||
| 29 PCT lymphocytes | 8 ALK PHOS | 8 ALK PHOS | |||
| 31 ABS neutrophils | 9 calciu | comp3 | 4 AST | ||
| 32 ABS basophils | 10 PT | 6 bilirubin direct | |||
| Red blood cell group | 11 RBC | 18 platelets | comp4 | 10 PT | |
| 12 RDW | 17 phosphorus | 23 glucose | |||
| 18 platelets | 19 WBC | comp5 | 13 sodium | ||
| 26 hemoglobulin | 21 creatinine | 20 chloride | |||
| 27 MCH | 22 PCT eosinophils | 15 potassium | |||
| 28 hematocrit | 23 glucose | comp6 | 24 MCV | ||
| 24 MCV | 24 MCV | 27 MCH | |||
| Liver function group | 2 ALT | 25 PCT monocytes | comp7 | 3 serum albumin | |
| 3 serum albumin | 27 MCH | 5 PCT basophils | |||
| 4 AST | 28 hematocrit | 7 bilirubin indirect | |||
| 6 bilirubin direct | 29 PCT lymphocytes | 9 calcium | |||
| 7 bilirubin indirect | 31 ABS neutrophils | 11 RBC | |||
| 8 ALK PHOS | comp2 | 13 sodium | 12 RDW | ||
| 10 PT | 20 chloride | 16 total protein | |||
| 16 total protein | 15 potassium | 14 HBA1C | |||
| Kidney group | 9 calcium | 16 total protein | 18 platelets | ||
| 13 sodium | comp3 | 3 serum albumin | 19 WBC | ||
| 15 potassium | 5 PCT basophils | ||||
| 17 phosphorus | 11 RBC | ||||
| 20 chloride | 12 RDW | ||||
| 30 magnesium | 14 HBA1C | ||||
| 21 creatinine | 26 hemoglobin | ||||
| Diabetes group | 14 HBA1C | 30 magnesium | |||
| 23 glucose | 32 ABS basophils | ||||
The 32 combo embeddings from combo model were grouped according to their organ system (grouping strategy 1) and their correlation matrix (grouping strategy 2 and grouping strategy 3). Please see Table S2 for the individual variables that comprise each combo variable. The numbers in front of each combo variable from 1 to 32 correspond to the numbers shown in Table S2. PCT, percent [%]; PT, prothrombin time; ALK, alkaline; PHOS, phosphorus; ABS, absolute; RBC, red blood cell; RDW, red cell diameter width; WBC, white blood cell; MCV, mean cell volume; MCH, mean cell hemoglobin.