Table 6.
Genotypic and allelic frequency distribution analysis of the GPX1 rs1050450 variant in migraineurs according to the typical duration of migraine attacks (≤24 vs. >24 h).
| GPX1 rs1050450 | Attack duration (N = 213) | OR (95% CI) | p | ORadj (95% CI)* | padj * | |||
|---|---|---|---|---|---|---|---|---|
| ≤24 h (N = 158) | >24 h (N = 55) | |||||||
| N | (%) | n | (%) | |||||
| CC | 81 | (51.3) | 20 | (36.4) | 1.0 (reference) | – | – | –i |
| CT | 66 | (41.8) | 26 | (47.3) | 1.595 (0.819–3.110) | 0.168 | 1.559 (0.796–3.057) | 0.196 |
| TT | 11 | (7.0) | 9 | (16.4) | 3.314 (1.210–9.077) | 0.023 ** | 3.973 (1.345–11.734) | 0.013 |
| CT + TT | 77 | (48.7) | 35 | (63.6) | 1.841 (0.979–3.463) | 0.057 | 1.784 (0.943–3.375) | 0.075 |
| CT | 66 | (41.8) | 26 | (47.3) | 1.0 (reference) | – | – | –ii |
| TT | 11 | (7.0) | 9 | (16.4) | 2.077 (0.771–5.595) | 0.143 | 2.223 (0.793–6.232) | 0.129 |
| TT + CC | 92 | (58.2) | 29 | (52.7) | 0.800 (0.432–1.482) | 0.478 | 0.836 (0.448–1.560) | 0.573 |
| TT | 11 | (7.0) | 9 | (16.4) | 1.0 (reference) | – | – | –iii |
| CT + CC | 147 | (93.0) | 46 | (83.6) | 0.382 (0.149–0.980) | 0.040 | 0.362 (0.138–0.951) | 0.039 |
| C | 228 | (72.2) | 66 | (60.0) | 1.0 (reference) | – | – | –iv |
| T | 88 | (27.8) | 44 | (40.0) | 1.727 (1.097–2.719) | 0.018 | - | - |
*
Adjusted for age, gender, BMI, and smoking status.
**
Two-tailed Fisher's Exact test.
Bold values are considered statistically significant (p < 0.05).
i
Power = 0.617.
ii
Power = 0.821.
iii
Power = 0.807.
iv
Power = 0.901.