Table 8.
Association analysis of the CAT rs1001179 variant with migraine triggers.
| Sleep changes | GG | (%) | GA | (%) | AA | (%) | OR (95% CI) | p | ORadj (95% CI)* | padj * | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes (n = 71) | 46 | (64.8) | 17 | (23.9) | 8 | (11.3) | GG vs. GA vs. AA | - | 0.013 | - | 0.017 i |
| No (n = 131) | 69 | (52.7) | 56 | (42.7) | 6 | (4.6) | GG vs. GA + AA | 1.653 (0.911–2.999) | 0.097 | 1.604 (0.878–2.931) | 0.125 |
| G | (%) | A | (%) | AA vs. GA + GG | 2.646 (0.880–7.955) | 0.087** | 2.816 (0.923–8.593) | 0.069 | |||
| Yes (n = 142) | 109 | (76.8) | 33 | (23.2) | GA vs. GG + AA | 0.422 (0.221–0.804) | 0.008 | 0.427 (0.222–0.821) | 0.011 ii | ||
| No (n = 262) | 194 | (74.0) | 68 | (26.0) | G vs. A | 1.158 (0.718–1.866) | 0.547 | - | - | ||
| Weather changes | GG | (%) | GA | (%) | AA | (%) | |||||
| Yes (n = 57) | 32 | (56.1) | 18 | (31.6) | 7 | (12.3) | GG vs. GA vs. AA | 0.154 | 0.117iii | ||
| No (n = 145) | 83 | (57.2) | 55 | (37.9) | 7 | (4.8) | GG vs. GA + AA | 0.956 (0.515–1.774) | 0.887 | 0.964 (0.510–1.822) | 0.910 |
| G | (%) | A | (%) | AA vs. GA + GG | 2.760 (0.922–8.262) | 0.071** | 3.164 (1.022–9.801) | 0.046 iv | |||
| Yes (n = 114) | 82 | (71.9) | 32 | (28.1) | GA vs. GG + AA | 0.755 (0.394–1.449) | 0.398 | 0.717 (0.366–1.403) | 0.331 | ||
| No (n = 290) | 221 | (76.2) | 69 | (23.8) | G vs. A | 0.800 (0.490–1.306) | 0.372 | - | - |
*
Adjusted for age, gender, BMI, and smoking status.
**
Two-tailed Fisher's Exact test.
Bold values are considered statistically significant (p < 0.05).
i
Power = 0.975.
ii
Power = 0.999.
iii
Power = 0.975.
iv
Power = 0.999.