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. 2023 Jan 9;16:1051175. doi: 10.3389/fnbeh.2022.1051175

FIGURE 1.

FIGURE 1

Motor function in Shank3-transgenic mice. Muscle function is analyzed in male and female wildtype, Shank3(+/–), and Shank3(–/–) mice at adolescent and adult age by determining (A,B) the muscle strength and (C,D) the grid hang time in the grid hanging test. (E,F) General locomotion was measured as the distance moved during a 30 min trial in the open field test. (G) Representative tracking images of the open field test from a wildtype and a Shank3(–/–) mouse are displayed. Motor memory and coordination were tested in three trials per day on five consecutive days on the accelerating Rotarod (4 to 40 rotations per minute within 5 min). (H–K) The maximal velocity, when the animal fell from the rod, is displayed. Asterisks (*) indicate significant differences between wildtype and Shank3(–/–) mice; # indicates significant differences between Shank3(+/–) and Shank3(–/–) mice. All data are represented as means with SEM with 9–11 animals per group. Significance levels (p-values) are set to 0.05 (p ≤ 0.05*/#, p ≤ 0.01**/##, p ≤ 0.001***/###, p ≤ 0.0001****) with 95% confidence interval. See Supplementary Table 2 for detailed statistical information.