Table 1.
A List of 10 Differentially Expressed Genes Randomly Selected from Our Study and Their Changes Identified in Older Children and Adults with AD on the Basis of the Literature
| DEG | Children Aged 0‒1 y |
Tissue, Down/Up | Older Children | Tissue, Down/Up | Adults | Tissue, Down/Up |
|---|---|---|---|---|---|---|
| IL18RAP | This study | PBMCs; Down |
Brunner et al. (2019) 4 mo, 5 y |
AD LS versus HC skin; Up | Ewald et al. (2015) and Hirota et al. (2012) | Susceptibility loci for AD; AD LS versus NS, Up |
| IL18R1 | This study | PBMCs; Down |
NA | Hirota et al. (2012) | Susceptibility loci for AD | |
| IL1β | This study | PBMCs; Up |
Cole et al. (2014) 6‒16 years |
AD NS versus HC skin; Down |
McAleer et al. (2019) and Thijs et al. (2018) | AD versus HC Serum, Up; AD versus HC SC, Down |
| TNF | This study | PBMCs; Up |
Brunner et al. (2019) Sumimoto et al. (1992) 1‒15 y |
AD LS versus HC skin, Up; AD NS versus HC skin, Up; AD versus HC Plasma, Up |
Suarez-Farinas et al. (2015) and Thijs et al. (2018) | AD LS versus NS, Up AD versus HC Serum, Up |
| TREM1 | This study | PBMCs; Up |
NA | Suarez-Farinas et al. (2015) and Thijs et al. (2018) | AD versus HC Serum, Up AD LS versus NS, Up |
|
| EGR3 | This study | PBMCs; Up |
NA | Suarez-Farinas et al. (2011) | AD LS versus HC skin, Down; AD NS versus HC skin, Down | |
| EGR2 | This study | PBMCs; Up |
Brunner et al. (2019) 4 mo, 5 y |
AD LS versus HC skin, Down; AD NS versus HC skin, Down |
Hirota et al. (2012) | Susceptibility loci for AD |
| EGR1 | This study | PBMCs; Up |
Brunner et al. (2019) 4 mo, 5 y Cole et al. (2014) 6‒16 y |
AD LS versus HC skin, Down; AD NS versus HC skin, Down; AD NS versus HC skin; Up |
Suarez-Farinas et al. (2011) | AD LS versus HC skin, Up; AD NS versus HC skin, Up |
| NLRP3 | This study | PBMCs; Up |
Brunner et al. (2019) | AD LS versus HC skin, Down; AD NS versus HC skin, Down |
Niebuhr et al. (2014) | AD LS versus HC skin, Down |
| FOSL1 | This study | PBMCs; Up |
Brunner et al. (2019) 6‒16 y Cole et al. (2014) 6‒16 y |
AD LS versus HC skin, Up AD NS versus HC skin; Up |
Ewald et al. (2015) and Suarez-Farinas et al. (2011) | AD LS versus HC skin, Up; AD LS versus AD NL skin, Up; AD LS versus NS, Up |
Abbreviations: AD, atopic dermatitis; DEG, differentially expressed gene; Down, downregulated; HC, healthy control; LS, lesional skin; NA, nonavailable; NS, nonlesional skin; SC, stratum corneum; Up, upregulated.