Table 6.
GO Enrichment and Pathway Analyses of Hub Genes
| GO Term | Gene Count | P-Value |
|---|---|---|
| Biological process | ||
| Platelet degranulation | 7 | 5.39E-10 |
| Platelet activation | 5 | 4.64E-06 |
| Extracellular matrix organization | 5 | 3.80E-05 |
| Cell division | 5 | 3.56E-04 |
| Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | 3 | 6.29E-04 |
| Platelet aggregation | 3 | 7.73E-04 |
| Blood coagulation | 4 | 7.86E-04 |
| Cell adhesion | 5 | 9.88E-04 |
| Mitotic nuclear division | 4 | 0.002 |
| Anaphase-promoting complex-dependent catabolic process | 3 | 0.003 |
| Positive regulation of calcidiol 1-monooxygenase activity | 2 | 0.003 |
| Sequestering of triglyceride | 2 | 0.004 |
| Sister chromatid cohesion | 3 | 0.005 |
| Positive regulation of fever generation | 2 | 0.005 |
| Inflammatory response | 4 | 0.006 |
| Regulation of establishment of endothelial barrier | 2 | 0.007 |
| Positive regulation of protein phosphorylation | 3 | 0.007 |
| Cytokine-mediated signaling pathway | 3 | 0.008 |
| Regulation of chromosome segregation | 2 | 0.008 |
| Negative regulation of lipid storage | 2 | 0.008 |
| Immune response | 4 | 0.008 |
| Positive regulation of ubiquitin-protein ligase activity | 2 | 0.009 |
| Positive regulation of chemokine biosynthetic process | 2 | 0.010 |
| Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | 3 | 0.010 |
| Positive regulation of heterotypic cell-cell adhesion | 2 | 0.011 |
| Regulation of cell proliferation | 3 | 0.015 |
| Regulation of I-kB kinase/NF-kB signaling | 2 | 0.015 |
| Positive regulation of membrane protein ectodomain proteolysis | 2 | 0.015 |
| Positive regulation of VEGF receptor signaling pathway | 2 | 0.016 |
| Negative regulation of lipid catabolic process | 2 | 0.016 |
| Cell‒substrate adhesion | 2 | 0.017 |
| Proteasome-mediated ubiquitin-dependent protein catabolic process | 3 | 0.018 |
| Blood coagulation, intrinsic pathway | 2 | 0.018 |
| Positive regulation of leukocyte chemotaxis | 2 | 0.018 |
| Positive regulation of protein export from the nucleus | 2 | 0.019 |
| Positive regulation of NF-kB import into the nucleus | 2 | 0.021 |
| Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 2 | 0.023 |
| Positive regulation of IL-8 production | 2 | 0.026 |
| Positive regulation of gene expression | 3 | 0.028 |
| Positive regulation of phagocytosis | 2 | 0.029 |
| Lipopolysaccharide-mediated signaling pathway | 2 | 0.032 |
| Protein kinase B signaling | 2 | 0.033 |
| Positive regulation of nitric oxide biosynthetic process | 2 | 0.043 |
| Positive regulation of IL-6 production | 2 | 0.045 |
| Positive regulation of IFN-γ production | 2 | 0.046 |
| Positive regulation of cell division | 2 | 0.047 |
| Cellular component | ||
| Platelet alpha granule lumen | 5 | 1.72E-07 |
| Cell surface | 5 | 0.001 |
| Extracellular region | 7 | 0.002 |
| Kinetochore | 3 | 0.003 |
| Extracellular space | 6 | 0.006 |
| Membrane | 7 | 0.012 |
| Platelet alpha granule membrane | 2 | 0.012 |
| Spindle mid-zone | 2 | 0.018 |
| Anaphase-promoting complex | 2 | 0.021 |
| Cytosol | 8 | 0.023 |
| ER to Golgi transport vesicle | 2 | 0.024 |
| Integrin complex | 2 | 0.025 |
| Integral component of plasma membrane | 5 | 0.038 |
| Spindle microtubule | 2 | 0.040 |
| Cytoplasmic microtubule | 2 | 0.047 |
| Molecular function | ||
| Protein binding | 16 | 0.002 |
| Protease binding | 3 | 0.005 |
| Identical protein binding | 5 | 0.006 |
| Extracellular matrix binding | 2 | 0.026 |
| Enzyme binding | 3 | 0.043 |
| Chemokine activity | 2 | 0.048 |
| KEGG pathway | ||
| Hematopoietic cell lineage | 5 | 1.09E-05 |
| ECM‒receptor interaction | 4 | 3.96E-04 |
| Platelet activation | 4 | 0.001 |
| Cytokine‒cytokine receptor interaction | 4 | 0.008 |
| Hypertrophic cardiomyopathy | 3 | 0.008 |
| Dilated cardiomyopathy | 3 | 0.009 |
| Osteoclast differentiation | 3 | 0.021 |
| Alzheimer's disease | 3 | 0.033 |
| Focal adhesion | 3 | 0.048 |
Hub genes identified in PPI network were used for GO enrichment and pathway analyses using DAVID database.
Abbreviations: ECM, extracellular matrix; ER, endoplasmic reticulum; GO, gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; PPI, protein‒protein interaction.