Figure 1.

(A) Body weight after sacrifice (B) Weight to length ratio of the colon of both strains. (C–F) Hematoxylin eosin staining in 20-week-old IL-10-deficient mice. Representative images of: inflammatory infiltrate, epithelial stratification, focal erosion, and mucin depletion, respectively. (G) Comparison of histological scoring of both strains of all ages (5 animals for each strain and age group were used in this analysis). (H) Measurement of the Mieloperoxidase (MPO) enzyme activity by colorimetric reaction at 10, 20, and 57 weeks of age in both strains made in three independent replicates. In all graphs, C57Bl/6 wild type (WT) group was represented in black and IL-10 deficient mice (IL-10^−/−) group in white. ^#p < 0.05 with respect to wild type (WT).