Table 2.
Pairs of brain regions showing significant differences in FC between groups when performing a one-way ANOVA.
| Network | ROI | Network | ROI | P value | Post hoc FC (SD) |
|---|---|---|---|---|---|
| Cerebellum | Cerebellum: Crus II (left) | DMN | Parietal lobe | 0.0007 | AD > EMCI 0.38 (0.2) > 0.13(0.32) |
| Cerebellum 2nd Non-motor: VIIB (right) | Sensory motor | Central region: Postcentral gyrus (left) | 0.0021 | AD > EMCI 0.47 (0.24) > 0.25 (0.23) | |
| Vermis 9 | Visual II | Occipital superior (Left) | 0.0022 | AD > NC 0.34 (020) > 0.13 (0.25) | |
| Visual I | Occipital lobe: medial surface, calcarine fissure (left) | Visual II | Occipital lobe (lateral): Superior occipital gyrus (right) | 0.0007 | AD > EMCI 0.67 (0.17) > 0.50 (0.20) |
| Occipital lobe: inferior surface, Lingual gyrus (right) | Visual II | Occipital inferior gyrus (right) | 0.0015 | LMCI > EMCI; NC > EMCI 0.62 (0.12) > 0.49 (0.21); 0.62 (0.16) | |
| Auditory | Temporal lobe: middle temporal gyrus (right) | Visual II | Occipital lobe (lateral): Superior occipital gyrus (left) | 0.0025 | AD < NC 0.11 (0.29) < 0.34 (0.20) |
| Basal ganglia | Caudate (right) | Dorsal left | Frontal lobe: Inferior frontal gyrus | 0.0022 | AD > NC 0.45 (0.19) > 0.25 (0.25) |
| Subcortical gray nuclei: Caudate nucleus (left) | Dorsal left | Temporal lobe: middle temporal gyrus (left) | 0.0022 | AD > NC 0.39 (0.21) > 0.22 (0.23) | |
| Thalamus | Sub cortical gray nuclei (right) | Ventrolateral prefrontal cortex | Frontal lobe: Inferior frontal gyrus triangular part (Left) | 0.0008 | AD > NC 0.50 (0.14) > 0.30 (0.20) |
The table displays the ROI to ROI Functional connectivity (FC) results and the differences between groups. HC, healthy controls; EMCI, early mild cognitive impairment; LMCI, late mild cognitive impairment AD, Alzheimer’s disease; DMN, default mode network.