FIGURE 4.

Relative frequency of patients that meet cardiovascular risk threshold for each protein study. 12 studies (Ridker et al.,⁴¹ Matsumoto et al.,²⁴ Meuwese et al.,²⁵ Morange et al.,²⁰ Canoui-Poitrine et al.,⁴⁴ Gonçalves et al.,³⁷ Wang et al.,³⁶ Herder et al.,³⁹ Pai et al.,³⁸ Doi et al.,³⁴ Herder et al.,³⁹ Persson et al.³¹) assessing the association of ten proteins (IL-6, SELE, MPO, vWF, CXCL10, CSTB, TNF-R1, NT-proBNP, IL-8, U-PAR) with primary cardiovascular (CV) risk in non-CVD populations were included in the analysis. The CV risk threshold for each protein was calculated from its respective study in the literature, and compared with each patient’s protein levels at baseline and after treatment. The frequency of patients with protein levels above a CV risk threshold in a given study, both before and after treatment, is shown here