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Epithelial barrier integrity in hypoxia apical-out organoids. Confocal microscopy demonstrated that no diffusion of the 4 kDa FITC-dextran solution in untreated organoids (top row) occurred, thus indicating strong barrier integrity. In contrast, treatment of organoids with 2 mM EDTA (bottom row) disrupted the junctions and the dextran diffused into the intercellular space. Scale bars: 100 μm (left and middle) and 50 μm (right).
