Fig. 1.
Association of prostate cancer–specific extracellular vesicle levels with tumor burden in oligometastatic and metastatic prostate cancer. (A) Representative scatterplots showing nanoscale flow cytometric detection of PSMA- and STEAP1-positive extracellular vesicles (EVs) from plasma of 1 patient with oligometastatic castration-resistant prostate cancer (omCRPC). (B, C) Comparisons are shown in levels of PSMA-positive (B) and STEAP1-positive EVs (C) in localized prostate cancer after radical prostatectomy (n = 22), omCRPC (n = 79), and metastatic castration-resistant prostate cancer (n = 40). ***P < .001 by Kruskal-Wallis test.