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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Nat Immunol. 2022 Oct 31;23(12):1788–1798. doi: 10.1038/s41590-022-01328-6

Extended Data Figure 1. Overlap in differentially expressed genes/modules and kinetics of common module clusters.

Extended Data Figure 1.

A-B) Histograms of overlap in DEGs (A) or differentially expressed modules (B) between vaccines. A gene/module is shared with another vaccine if it is significantly (FDR < 0.05) regulated in the same direction, irrespective of time point. Blue bars, number of genesets shared (y-axis) between the same number of vaccines (x-axis). Grey bars represent the null distribution generated by n=10,000 permutations of gene/module labels within vaccine + timepoint groups. Data are presented as mean values +/− 95% confidence interval. C) Kinetics of the mean FC of cluster 2 BTMs across vaccines. D) Kinetics of the mean FC of cluster 4 modules across vaccines.