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. 2023 Jan 9;10:1094124. doi: 10.3389/fcell.2022.1094124

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Copyright © 2023 Marr, Zamboulis, Werling, Felder, Dudhia, Pitsillides and Thorpe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD146 cell populations demarcated a vascular network indicative of a vascular cell niche within the interfascicular matrix. (A) 3D imaging of (i) CD146 and (ii) CD146 and nuclei (DAPI, blue) confirmed that the IFM was enriched with CD146 cell populations as part of an interconnected vessel network. Images of labelled transverse SDFT sections demonstrating colocalisation of Desmin with CD31 and CD146 (B,C) and CD146 with LAMA4 (D) indicating that CD146 represents a marker of interfascicular vascular cell populations resident within laminin-rich vessels. Nuclei = DAPI (blue). IFM is demarcated by dashed lines in transverse images. Scale bar = 50 µm. Images represent maximum projection of 30 µm section.