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. Author manuscript; available in PMC: 2023 Dec 22.
Published in final edited form as: Cell. 2022 Dec 22;185(26):4921–4936.e15. doi: 10.1016/j.cell.2022.11.023

Figure 1. Multi-omic data from the EDIA cohort.

Figure 1.

A) Schematic illustration of metagenomic and metabolomic data. Number of samples (n) after quality control at each time point is indicated. B) t-distributed stochastic neighbor embedding (t-SNE) ordination of gut microbiome profiles based on Bray-Curtis dissimilarities of species-level abundances from metagenomic data. C) t-SNE ordination of gut metabolite profiles based on log-scaled and z-score-normalized abundances of n=858 metabolites annotated using reference standards. D-E) Effects of factors on (D) species-level taxonomic composition (Bray-Curtis dissimilarities) and (E) metabolomic profiles (restricted to features annotated using standards) in infants according to cross-sectional PERMANOVA analyses. Factors were assessed in combination, while ordered by individual log10-transformed p-values from initial PERMANOVA analysis of each factor. ‘Infant formula’ comprises three categories: regular, hydrolyzed, and no formula. See also Figure S1; Tables S1-2.