Skip to main content
. Author manuscript; available in PMC: 2023 Jan 23.
Published in final edited form as: Biochem Soc Trans. 2020 Apr 29;48(2):517–528. doi: 10.1042/BST20190675

Figure 2.

Figure 2.

Proposed roles of MASPs in regulation of ion transport in the kidneys. Corin-generated ANP binds to its receptor NPR-A and enhances its guanylyl cyclase activity. CyclicGMP prevents sodium reabsorption by inhibiting activity of several ion transport proteins in different segments of nephron. Hepsin mediates shedding of the GPI-anchored protein uromodulin, leading to a decreased activity of Na+, K+, Cl− cotransporter NKCC2 in the thick ascending limb. Finally, several MASPs, including prostasin, matriptase, and TMPRSS4, have been proposed to activate the epithelial sodium channel ENaC, suggesting their possible involvement in sodium reabsorption in the distal tubules and collecting ducts. Abbreviations: ANP, atrial natriuretic peptide; cGMP, cyclic guanosine monophosphate; ENaC, epithelial sodium channel; GPI, glycosylphosphatidylinositol, GTP, guanosine triphosphate; Na/K ATPase, sodium-potassium adenosine triphosphatase; NaPi-IIa, sodium-phosphate cotransporter IIa; NHE, sodium-proton exchanger; NKCC2, sodium-potassium-chloride cotransporter; NPR, natriuretic peptide receptor.