Table 2.
Univariate analysis of portal vein thrombus resolution events
| Variable | Coefficient | Stat | HR (95%CI) | P value |
|---|---|---|---|---|
| Age | 0.02 | 2.86 | 1.02(1.00,1.04) | 0.0909 |
| BMI | 0.01 | 0.01 | 1.00(0.94,1.08) | 0.9029 |
| Drinking | -0.35 | 2.10 | 0.70(0.44,1.13) | 0.1473 |
| Smoking | -0.48 | 3.54 | 0.62(0.38,1.02) | 0.0599 |
| Liver disease | ||||
| Cirrhosis | -0.59 | 3.46 | 0.55(0.30,1.03) | 0.0628 |
| Hepatic carcinoma | -0.32 | 0.81 | 0.73(0.37,1.45) | 0.3684 |
| Comorbidities | ||||
| Atrial fibrillation | 0.67 | 2.04 | 1.95(0.78,4.88) | 0.1530 |
| Coronary heart disease | 0.41 | 1.29 | 1.50(0.75,3.02) | 0.2562 |
| Cerebral infarction | 0.22 | 0.40 | 1.24(0.64,2.41) | 0.5257 |
| Diabetes | -0.19 | 0.61 | 0.83(0.52,1.33) | 0.4345 |
| Ascites | -0.41 | 3.31 | 0.67(0.43,1.03) | 0.0687 |
| Splenomegaly | -0.34 | 2.37 | 0.71(0.47,1.10) | 0.1235 |
| Current GIB | -0.13 | 0.26 | 0.88(0.54,1.44) | 0.6126 |
| History of GIB | -0.34 | 1.82 | 0.71(0.44,1.17) | 0.1776 |
| History of abdominal surgery | 0.35 | 2.39 | 1.42(0.91,2.23) | 0.1218 |
| History of anticoagulants | 0.63 | 3.59 | 1.87(0.98,3.57) | 0.0580 |
| History of blood transfusion | -0.11 | 0.21 | 0.90(0.56,1.44) | 0.6501 |
| History of anti-hypertensive drugs | -0.29 | 0.39 | 0.75(0.30,1.86) | 0.5334 |
| History of endoscopic operation | 0.44 | 1.81 | 1.56(0.82,2.98) | 0.1781 |
| History of hepatic encephalopathy | -0.48 | 0.65 | 0.62(0.20,1.97) | 0.4197 |
| History of abdominal infection | -0.51 | 5.23 | 0.60(0.39,0.93) | 0.0222 |
| The site of thrombus involvement | ||||
| Main portal vein thrombosis | -0.13 | 0.26 | 0.88(0.54,1.45) | 0.6112 |
| Portal branch thrombosis | -0.10 | 0.20 | 0.91(0.59,1.39) | 0.6514 |
| SMV thrombosis | -0.28 | 1.38 | 0.76(0.48,1.21) | 0.2405 |
| Splenic vein thrombosis | 0.17 | 0.39 | 1.18(0.70,1.99) | 0.5301 |
| Esophageal varices | -0.44 | 3.38 | 0.64(0.40,1.03) | 0.0660 |
| Red color sign | -0.44 | 2.53 | 0.64(0.37,1.11) | 0.1117 |
| Degree of esophageal varices | ||||
| mild | REF | |||
| moderate | 0.20 | 0.20 | 1.22(0.51,2.94) | 0.6526 |
| severe | 0.23 | 0.29 | 1.26(0.55,2.88) | 0.5896 |
| CTP classification | ||||
| Level A | REF | |||
| Level B | -0.50 | 4.47 | 0.61(0.38,0.96) | 0.0345 |
| Level C | -0.23 | 0.24 | 0.79(0.31,2.02) | 0.6276 |
| Laboratory findings | ||||
| PT > 12.1(s) | -0.20 | 0.35 | 0.82(0.42,1.60) | 0.5554 |
| INR > 1.5 | 0.04 | 0.01 | 1.05(0.45,2.45) | 0.9174 |
| D-dimer > 0.55(mg/L) | 0.03 | 0.01 | 1.03(0.41,2.56) | 0.9490 |
| WBC (× 109/L) | ||||
| < 3.5 | -0.19 | 0.54 | 0.83(0.51,1.36) | 0.4616 |
| > 9.5 | -0.07 | 0.05 | 0.93(0.52,1.68) | 0.8172 |
| RBC ≥ 3.8 (× 1012/L) | 0.41 | 3.26 | 1.51(0.97,2.37) | 0.0711 |
| HB ≥ 115(g/L) | 0.49 | 4.68 | 1.64(1.05,2.56) | 0.0306 |
| PLT ≥ 125 (× 109/L) | 0.21 | 0.90 | 1.23(0.80,1.89) | 0.3421 |
| CRP > 5(mg/L) | -0.64 | 8.16 | 0.53(0.34,0.82) | 0.0043 |
| ALB ≥ 40(g/L) | 0.65 | 6.39 | 1.91(1.16,3.15) | 0.0115 |
| ALT > 40(U/L) | -0.25 | 0.71 | 0.78(0.44,1.39) | 0.3983 |
| AST > 35(U/L) | 0.41 | 3.40 | 1.51(0.97,2.34) | 0.0652 |
| TBIL > 21(μmol/L) | 0.13 | 0.35 | 1.14(0.74,1.77) | 0.5528 |
| DBIL > 10.2(μmol/L) | -0.05 | 0.06 | 0.95(0.61,1.47) | 0.8068 |
| SCR > 92(μmol/L) | 0.01 | 0.01 | 1.00(0.56,1.78) | 0.9952 |
| TG > 2.26(mmol/L) | -0.29 | 0.52 | 0.75(0.34,1.64) | 0.4719 |
| HDL ≥ 1.15(mmol/L) | 0.10 | 0.20 | 1.11(0.71,1.73) | 0.6585 |
| LDL > 2.16(mmol/L) | 0.08 | 0.15 | 1.09(0.71,1.67) | 0.7023 |
| K < 3.5(mmol/L) | 0.14 | 0.27 | 1.15(0.67,1.98) | 0.6043 |
| AFP > 7(ng/mL) | 0.23 | 0.62 | 1.26(0.71,2.22) | 0.4307 |
| Treatment and symptoms after diagnosis of PVT | ||||
| Hepatic encephalopathy | -0.64 | 2.84 | 0.53(0.25,1.11) | 0.0919 |
| Endoscope ligation | 0.62 | 1.78 | 1.86(0.75,4.64) | 0.1825 |
| Abdominal infection | 0.22 | 0.35 | 1.25(0.60,2.59) | 0.5542 |
| Blood transfusion | -0.26 | 1.01 | 0.77(0.46,1.29) | 0.3161 |
| Abdominal surgery | 0.14 | 0.32 | 1.15(0.71,1.87) | 0.5732 |
| Thrombolytic therapy | 0.55 | 6.34 | 1.73(1.13,2.66) | 0.0118 |
| The drugs of thrombolytic therapy | ||||
| no drugs | REF | |||
| anticoagulants | 0.80 | 11.00 | 2.22(1.39,3.55) | 0.0009 |
| antiplatelets | 0.04 | 0.02 | 1.05(0.52,2.09) | 0.9017 |
| Anticoagulant drugs | ||||
| low molecular weight heparin | REF | |||
| warfarin | 1.56 | 1.83 | 4.78(0.50,46.07) | 0.1760 |
| Anticoagulant duration | 0.01 | 0.06 | 1.00(1.00,1.01) | 0.8009 |
HR Hazard ratio, CI Confidence interval, BMI Body mass index, GIB Gastrointestinal bleeding, SMV Superior mesenteric vein, PT Prothrombin time, INR International normalized ratio, WBC White blood cell, RBC Red blood cell, HB Hemoglobin, PLT Platelet count, CRP C-reactive protein, ALB Albumin, ALT Alanine aminotransferase, AST Aspartate aminotransferase, TBIL Total bilirubin, DBIL Direct bilirubin, SCR Serum creatinine, TG Triglyceride, HDL High-density lipoprotein, LDL Low-density lipoprotein, K Kalium, AFP Alpha-fetoprotein