Table 2.
Median OS and PFS using pseudo IPD from Kaplan-Meier curves
| Population | Frequentist analyses | Bayesian fractional polynomial meta-analyses | ||
|---|---|---|---|---|
| Median OS Months (95% CI) | Median PFS Months (95% CI) | Median OS Months (95% CI) | Median PFS Months (95% CI) | |
| ≥3rd line | 55.34 (46.60, 76.00) | 10.09 (9.25, 11.10) | 56.57 (47.8–68.78) | 9.78 (9.01–10.63) |
| ≥4th line | 40.63 (32.58, 52.12) | 8.41 (7.47, 9.48) | 39.89 (31.79–51.94) | 8.11 (7.3–9.04) |
| Representative cohorts ≥3rd line | 57.94 (46.60, 78.41) | 9.99(8.62, 11.10) | 58.67 (48.56–72.47) | 9.43 (8.57–10.4) |
| Representative cohorts ≥4th line | 42.02 (34.80, 55.34) | 8.33 (7.11, 9.56) | 41.63 (32.93–55.12) | 7.9 (7.02–8.93) |
*Frequentist results and median as estimated using Bayesian fractional polynomials