Skip to main content
. Author manuscript; available in PMC: 2023 Jan 23.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2021 Aug 17;56(6):621–639. doi: 10.1080/10409238.2021.1954597

Fig. 1: Hexameric helicase superfamilies and folds.

Fig. 1:

The core ASCE αβα binding fold (blue) has diverged into the RecA (pink) and AAA+ (green) families that make up all hexameric helicases. Select structural insertions and locations or specific motifs are indicated (yellow for ASCE, pink or green for RecA and AAA+, respectively). Dark green dotted lines and arrows show the helix two insert (H2I) that is specific to SF-VI and not found in SF-III helicases.